Crustecdysone
Cat. No.：YN373384
CAS No. ：5289-74-7
| 产品名称: | Crustecdysone |
| CAS No.: | 5289-74-7 |
| Chemical Name: | (5β)-2β,3β,14,20,22R,25-hexahydroxy-cholest-7-en-6-one |
| Synonyms: | β-蜕皮甾酮; 20-Hydroxyecdysone |
| 分子量: | 480.63 |
| 分子式: | C₂₇H₄₄O₇ |
| SMILES: | O[C@@H]1[C@H](O)C[C@](C(C=C2[C@]3([H])CC[C@@]4(C)[C@@]2(O)CC[C@]4([H])[C@](O)(C)[C@H](O)CCC(O)(C)C)=O)([H])[C@]3(C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Crustecdysone (20-Hydroxyecdysone) 是一种天然存在的蜕皮激素，源于露水草Cyanotis arachnoides C.B.Clarke, 可控制节肢动物的蜕皮和变态，它通过 20E 核受体复合物 EcR-USP 抑制半胱天冬酶 (Caspase) 活性并诱导自噬 (autophagy)。Crustecdysone 在心血管系统中具有调节或保护作用。Crustecdysone 是 Ecdysone (α-Ecdysone; HY-N0179) 的活性代谢物。 |
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Fallon, A.M., and Gerenday, A.Ecdysone and the cell cycle: Investigations in a mosquito cell lineJ. Insect Physiol.56(10),1396-1401(2010)
Boo, K.H., Lee, D., Jeon, G.L., et al.Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica NakaiBiosci. Biotechnol. Biochem.74(11),2226-2231(2010)
Cai, M.J., Dong, D.J., Wang, Y., et al.G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membraneCell Commun. Signal.12,11-16(2014)
Saez, E., Nelson, M.C., Eshelman, B., et al.Identification of ligands and coligands for the ecdysone-regulated gene switchProc. Natl. Acad. Sci. USA97(26),14512-14517(2000)
Karzenowski, D., Potter, D.W., and Padidam, M.Inducible control of transgene expression with ecdysone receptor: Gene switches with high sensitivity, robust expression, and reduced sizeBiotechniques39(2),191-192(2005)
