9-cis-Retinal
Cat. No.：YN374091
CAS No. ：514-85-2
| 产品名称: | 9-cis-Retinal |
| CAS No.: | 514-85-2 |
| Chemical Name: | 9-cis-retinal |
| Synonyms: | 9-顺式视黄醛 |
| 分子量: | 284.44 |
| 分子式: | C₂₀H₂₈O |
| SMILES: | CC(/C=C/C=C(\C=C\C1=C(CCCC(C)1C)C)C)=C\C=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 9-cis-Retinal 是天然的类视黄醇。饮食中的 99-cis-β-carotene 通过裂解成 9-cis-retinoids 生成 9-cis-Retinal。9-cis-Retinal 与细胞视黄醇结合蛋白-I (CRBP-1) 和 CRBP-II 的Kd分别为 8 nM 和 5 nM。9-cis-Retinal 加快了视网膜类器官中杆感光细胞的分化和成熟。 |
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Mertz, J.R., Shang, E., Piantedosi, R., et al.Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formationJ. Biol. Chem.272(18),11744-11749(1997)
Kane, M.A., Bright, F.V., and Napoli, J.L.Binding affinities of CRBPI and CRBPII for 9-cis-retinoidsBiochim. Biophys. Acta1810(5),514-518(2011)
Golovleva, I., Bhattacharya, S., Wu, Z., et al.Disease-causing mutations in the cellular retinaldehyde binding protein tighten and abolish ligand interactionsJ. Biol. Chem.278(14),12397-12402(2003)
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Parker, R.O., Fan, J., Nickerson, J.M., et al.Normal cone function requires the interphotoreceptor retinoid binding proteinJ. Neurosci.29(14),4616-4621(2009)
