Scyllo-Inositol
Cat. No.：YN374104
CAS No. ：488-59-5
| 产品名称: | Scyllo-Inositol |
| CAS No.: | 488-59-5 |
| Chemical Name: | (1r,2r,3r,4r,5r,6r)-cyclohexane-1,2,3,4,5,6-hexaol |
| Synonyms: | 鲨肌醇 |
| 分子量: | 180.16 |
| 分子式: | C₆H₁₂O₆ |
| SMILES: | O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1O)O)O)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Scyllo-Inositol 是一种淀粉样抑制剂，抑制 α-突触核蛋白聚集。Scyllo-Inositol 在体外可以稳定非纤维状无毒形式的淀粉样蛋白-β 肽 (amyloid-β)，逆转阿尔茨海默病小鼠模型的认知缺陷，降低突触毒性和淀粉样斑块。 |
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McLaurin, J., Golomb, R., Jurewicz, A., et al.Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit Αβ-induced toxicityJ. Biol. Chem.275(24),18495-18502(2000)
McLaurin, J., Kierstead, M.E., Brown, M.E., et al.Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse modelNat. Med.12(7),801-808(2006)
