4,6-Dioxoheptanoic acid
Cat. No.：YN374110
CAS No. ：51568-18-4
| 产品名称: | 4,6-Dioxoheptanoic acid |
| CAS No.: | 51568-18-4 |
| Chemical Name: | 4,6-dioxo-heptanoic acid |
| Synonyms: | Succinylacetone,4,6-二氧代庚酸 |
| 分子量: | 158.15 |
| 分子式: | C₇H₁₀O₄ |
| SMILES: | CC(=O)CC(=O)CCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4,6-Dioxoheptanoic acid 是一种有效的血红素生物合成抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sassa, S., and Kappas, A.Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetoneJ. Clin. Invest.71(3),625-634(1983)
Ebert, P.S., Hess, R.A., Frykholm, B.C., et al.Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme content and delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cellsbiochem. Biophys. Res. Commun.88(4),1382-1390(1979)
Moore, M.E., Koenig, A.E., Hilgartner, M.A., et al.Abnormal social behavior in mice with tyrosinemia type I is associated with an increase of myelin in the cerebral cortexMetab. Brain Dis.32(6),1829-1841(2017)
Stinton, C., Geppert, J., Greeman, K., et al.Newborn screening for Tyrosinemia type 1 using succinylacetone - a systematic review of test accuracyOrphanet J. Rare Dis.12(1),48(2017)
