6-Hydroxymelatonin
Cat. No.：YN374161
CAS No. ：2208-41-5
| 产品名称: | 6-Hydroxymelatonin |
| CAS No.: | 2208-41-5 |
| Chemical Name: | N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide |
| Synonyms: | |
| 分子量: | 248.28 |
| 分子式: | C₁₃H₁₆N₂O₃ |
| SMILES: | CC(NCCC1=CNC2=C1C=C(OC)C(O)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 6-Hydroxymelatonin 是褪黑素(Melatonin)通过 CYP1A2 代谢的主要代谢物。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Dubocovich, M.L., Masana, M.I., Iacob, S., et al.Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptorNaunyn-Schmiedeberg's Arch. Pharmacol.355(3),365-375(1997)
Dubocovich, M.L.Melatonin receptors: Are there multiple subtypes?Trends Pharamacol. Sci.16(2),50-56(1995)
Dubocovich, M.L.Characterization of a retinal melatonin receptorJ. Pharmacol. Exp. Ther.234(2),395-401(1985)
Lowes, D.A., Almawash, A.M., Webster, N.R., et al.Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsisBr. J. Anaesth.107(2),193-201(2011)
Maharaj, D.S., Maharaj, H., Daya, S., et al.Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicityJ. Neurochem.96(1),78-81(2006)
Härtter, S., Wang, X., Weigmann, H., et al.Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatoninJ. Clin. Psychopharmacol.21(2),167-174(2001)
