H-HoPro-OH
Cat. No.：YN374182
CAS No. ：3105-95-1
| 产品名称: | H-HoPro-OH |
| CAS No.: | 3105-95-1 |
| Chemical Name: | 2S-piperidinecarboxylic acid |
| Synonyms: | L-哌啶酸,H-HoPro-OH,L-Homoproline |
| 分子量: | 129.16 |
| 分子式: | C₆H₁₁NO₂ |
| SMILES: | O=C([C@H]1NCCCC1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | H-HoPro-OH 是赖氨酸的分解产物，它能在患有常染色体遗传性疾病的婴儿体液中积累，比如 Zellweger 综合征，新生儿肾上腺机能障碍。 |
| IC50和靶点: | |
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Chang, Y.F.Pipecolic acid pathway: The major lysine metabolic route in the rat brainBiochem. Biophys. Res. Commun.69(1),174-180(1976)
Chang, Y.F., Ghosh, P., and Rao, V.V.L-pipecolic acid metabolism in human liver: L-α-aminoadipate δ-semialdehyde oxidoreductaseBiochim. Biophys. Acta1038(3),300-305(1990)
Dodt, G., Kim, D.G., Reimann, S.A., et al.L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidasesBiochem. J.345 Pt. 3(Pt. 3),487-494(2000)
Feigenbaum, P., and Chang, Y.F.Pipecolic acid antagonizes barbiturate-enhanced GABA binding to bovine brain membranesBrain Res.372(1),176-179(1986)
Mihalik, S.J., Moser, H.W., Watkins, P.A., et al.Peroxisomal L-pipecolic acid oxidation is deficient in liver from Zellweger syndrome patientsPediatr. Res.25(5),548-552(1989)
