D-Erythro-dihydrosphingosine
Cat. No.：YN374326
CAS No. ：764-22-7
| 产品名称: | D-Erythro-dihydrosphingosine |
| CAS No.: | 764-22-7 |
| Chemical Name: | 2S-amino-1,3R-octadecanediol |
| Synonyms: | D-erythro-Sphinganine,D-赤式-C 18 - 二氢-D-神经鞘氨醇,C18-Dihydrosphingosine,Dihydrosphingosine,Octadecasphinganine |
| 分子量: | 301.51 |
| 分子式: | C₁₈H₃₉NO₂ |
| SMILES: | CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Pruett, S.T., Bushnev, A., Hagedorn, K., et al.Biodiversity of sphingoid bases ("sphingosines") and related amino alcoholsJ. Lipid Res.49(8),1621-1639(2008)
Shephard, G.S., van der Westhuizen, L., and Sewram, V.Biomarkers of exposure to fumonisin mycotoxins: A reviewFood Addit. Contam.24(10),1196-1201(2007)
Yin, J., Miyazaki, K., Shaner, R.L., et al.Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markersFEBS Lett.584(9),1872-1878(2010)
Merrill, A.H., Jr., Sereni, A.M., Stevens, V.L., et al.Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain basesJ. Biol. Chem.261(27),12610-12615(1986)
Merrill, A.H., Jr., Nimkar, S., Menaldino, D., et al.Structural requirements for long-chain (shingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compoundsBiochemistry28(8),3138-3145(1989)
Coste, O., Brenneis, C., Linke, B., et al.Sphingosine 1-phosphate modulates spinal nociceptive processingJ. Biol. Chem.283(47),32442-32451(2008)
Bu, S., Yamanaka, M., Pei, H., et al.Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblastsFASEB J.20(1),184-186(2006)
Bu, S., Kapanadze, B., Hsu, T., et al.Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathwayJ. Biol. Chem.283(28),19593-19602(2008)
