Farnesol
Cat. No.：YN374390
CAS No. ：4602-84-0
| 产品名称: | Farnesol |
| CAS No.: | 4602-84-0 |
| Chemical Name: | 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol |
| Synonyms: | 法呢醇 |
| 分子量: | 222.37 |
| 分子式: | C₁₅H₂₆O |
| SMILES: | C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Farnesol 是一种半萜醇，能够调节细胞间的通讯，并具有抑菌活性。 |
| IC50和靶点: | |
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Staines, A.G., Sindelar, P., Coughtrie, M.W., et al.Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1Biochem. J.384(Pt. 3),637-645(2004)
Takahashi, N., Kawada, T., Goto, T., et al.Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytesFEBS Lett.514(2-3),315-322(2002)
Lee, J.H., Kim, C., Kim, S.H., et al.Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathwayCancer Lett.360(2),280-293(2015)
Joo, J.H., Ueda, E., Bortner, C.D., et al.Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cellsBiochem. Pharmacol.97(3),256-268(2015)
Park, J.S., Kwon, J.K., Kim, H.R., et al.Farnesol induces apoptosis of DU145 prostate cancer cells through the PI3K/Akt and MAPK pathwaysInt. J. Mol. Med.33(5),1169-1176(2014)
Hornby, J.M., Jensen, E.C., Lisec, A.D., et al.Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesolAppl. Environ. Microbiol.67(7),2982-2992(2001)
Polke, M., Leonhardt, I., Kurzai, O., et al.Farnesol signalling in Candida albicans - more than just communicationCrit. Rev. Microbiol.13,1-14(2017)
