Zibotentan
Cat. No.：YN320085
CAS No. ：186497-07-4
| 产品名称: | Zibotentan |
| CAS No.: | 186497-07-4 |
| Chemical Name: | N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide |
| Synonyms: | ZD4054 |
| 分子量: | 424.43 |
| 分子式: | C₁₉H₁₆N₆O₄S |
| SMILES: | O=S(NC1=NC=C(C)N=C1OC)(C2=CC=CN=C2C3=CC=C(C4=NN=CO4)C=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zibotentan (ZD4054)是口服活性的内皮素A（ETA）受体特异性拮抗剂，IC50为21 nM。 |
| IC50和靶点: | [{name:"ETA:13 nM (Ki)"}] |
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| Solvent & Solubility: |
Morris, C.D., Rose, A., Curwen, J., et al.Specific inhibition of the endothelin A receptor with ZD4054: Clinical and pre-clinical evidenceBr. J. Cancer92(12),2148-2152(2005)
Rosanò, L., Di Castro, V., Spinella, F., et al.ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivoMol. Cancer Ther.6(7),2003-2011(2007)
