A-192621
Cat. No.：YN320532
| 产品名称: | A-192621 |
| CAS No.: | 195529-54-5 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 558.66 |
| 分子式: | C₃₃H₃₈N₂O₆ |
| SMILES: | O=C([C@H]1[C@H](C2=CC=C(OCCC)C=C2)N(CC(NC3=C(CC)C=CC=C3CC)=O)C[C@@H]1C4=CC=C(OCO5)C5=C4)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-192621 是一种有效的非肽，口服活性，选择性内皮素 B (ETB) 受体拮抗剂，IC50为 4.5 nM，Ki为 8.8 nM。A-192621 的选择性比 ETA高 636 倍 (IC50为 4280 nM，Ki为 5600 nM)。A-192621 促进 PASMC 细胞凋亡，并引起动脉血压升高和血浆 ET-1 水平升高。 |
| IC50和靶点: | [{name:"ETB:4.5 nM (IC50)"},{name: "ETB:8.8 nM (Ki)"},{name: "ETA:4280 nM (IC50)"},{name: "ETA:5600 nM (Ki)"}] |
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