BQ-123
Cat. No.：YN320582
| 产品名称: | BQ-123 |
| CAS No.: | 136553-81-6 |
| Chemical Name: | cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl) |
| Synonyms: | BQ123 |
| 分子量: | 610.70 |
| 分子式: | C₃₁H₄₂N₆O₇ |
| SMILES: | O=C(N[C@](C(N(CCC1)[C@]1([H])C2=O)=O)([H])CC(O)=O)[C@H](NC([C@@H](NC([C@H](N2)C(C)C)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BQ-123 是一种选择性内皮素 A 受体(ETAR)拮抗剂，IC50值为 7.3 nM，Ki值为 25 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ihara, M., Noguchi, K., Saeki, T., et al.Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptorLife Sci.50(4),247-255(1992)
Sakamoto, A., Yanagisawa, M., Sawamura, T., et al.Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonistsJ. Biol. Chem.268(12),8547-8553(1993)
Zamora, M.A., Dempsey, E.C., Walchak, S.J., et al.BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cellsAm. J. Respir. Cell Mol. Biol.9(4),429-433(1993)
Warner, T.D., Allcock, G.H., and Vane, J.R.Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065Br. J. Pharmacol.112(1),207-213(1994)
Erdogan, H., Ekici, F., Katar, M., et al.The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in ratsHum. Exp. Toxicol.33(10),1008-1016(2014)
