ABT-546
Cat. No.：YN320750
| 产品名称: | ABT-546 |
| CAS No.: | 212481-66-8 |
| Chemical Name: | |
| Synonyms: | A-216546 |
| 分子量: | 532.71 |
| 分子式: | C₃₀H₄₈N₂O₆ |
| SMILES: | O=C([C@H]1[C@H](CC(C)(C)CCC)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C2=CC(OC)=C(OCO3)C3=C2)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ABT-546 (A-216546) 是一种有效的，高选择性和活性的内皮素ETA受体拮抗剂，对 [125I]-内皮素-1 与克隆的人ETA结合的Ki为 0.46 nM。ABT-546 对ETA的选择性比对 ETB受体的选择性高 25,000 倍以上。ABT-546 阻断内皮素-1 诱导的花生四烯酸释放和磷脂酰肌醇水解，IC50分别为 0.59 nM 和 3 nM。 |
| IC50和靶点: | [{name:"ETA:0.46 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
