BQ-788 sodium salt
Cat. No.：YN321046
| 产品名称: | BQ-788 sodium salt |
| CAS No.: | 156161-89-6 |
| Chemical Name: | N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine, monosodium salt |
| Synonyms: | BQ-788 SODIUM;BQ789 Sodium Salt;1-ELAIDYLPHOSPHOCHOLINE, >97%;BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT;N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-;2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle;DMpc-gaMMa-MeLeu-D-Trp |
| 分子量: | 663.78 |
| 分子式: | C₃₄H₅₀N₅NaO₇ |
| SMILES: | CCCC[C@H](C(O[Na])=O)NC([C@@H](CC1=CN(C(OC)=O)C2=CC=CC=C12)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BQ-788 sodium salt 是一种有效，选择性的ETB受体拮抗剂，在人类 Girrardi 心脏细胞中抑制 ET-1 与 ETB 受体结合的IC50为 1.2 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Okada, M., and Nishikibe, M.BQ-788, a selective endothelin ETB receptor antagonistCardiovasc. Drug Rev.20(1),53-66(2002)
Ishikawa, K., Ihara, M., Noguchi, K., et al.Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788Proc. Natl. Acad. Sci. USA91(11),4892-4896(1994)
Ługowska-Umer, H., Umer, A., Kuziemski, K., et al.The protective effect of endothelin receptor antagonists against surgically induced impairment of gastrointestinal motility in ratsJ. Smooth Muscle Res.55,23-33(2019)
Ruetten, H., and Thiemermann, C.Effect of selective blockade of endothelin ETB receptors on the liver dysfunction and injury caused by endotoxaemia in the ratBr. J. Pharmacol.119(3),479-486(1996)
