Sulfisoxazole
Cat. No.：YN321451
| 产品名称: | Sulfisoxazole |
| CAS No.: | 127-69-5 |
| Chemical Name: | 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-benzenesulfonamide |
| Synonyms: | 磺胺异恶唑; Sulfafurazole |
| 分子量: | 267.30 |
| 分子式: | C₁₁H₁₃N₃O₃S |
| SMILES: | O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sulfisoxazole (Sulfafurazole) 是内皮素受体拮抗剂，是磺胺类抗生素。Sulfisoxazole 通过靶向内皮素受体 A，抑制乳腺癌外显子释放。 |
| IC50和靶点: | [{name:"ETA:0.60 μM (IC50)"},{name: "ETB:22 μM (IC50)"}] |
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Chan, M.F., Okun, I., Stavros, F.L., et al.Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screeningBiochem. Bioph. Res. Commun.201(1),228-234(1994)
Uchino, T., Sanyal, S.N., Yamabe, M., et al.Rescue of pulmonary hypertension with an oral sulfonamide antibiotic sulfisoxazole by endothelin receptor antagonistic actionsHypertens. Res.31(9),1781-1790(2008)
Nasr, T., Bondock, S., and Eid, S.Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moietyEur. J. Med. Chem.84,491-504(2014)
