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Euphorbiasteroid

Cat. No.:YN420303

  • CAS No. :28649-59-4

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    • 产品名称: Euphorbiasteroid
      CAS No.: 28649-59-4
      Chemical Name: benzeneacetic acid, (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
      Synonyms:千金子甾醇
      分子量:552.66
      分子式:C₃₂H₄₀O₈
      SMILES:CC(O[C@@](C[C@H](C)[C@@H]1OC(CC2=CC=CC=C2)=O)(C(/C(C)=C\[C@@H](C3(C)C)[C@@H]3CC[C@@]45CO5)=O)[C@@]1([H])[C@@H]4OC(C)=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Euphorbiasteroid 是续随子中的三环二萜,可抑制 tyrosinase 活性,增强AMPK的磷酸化,具有抗癌、抗病毒、抗肥胖及多重耐药调节作用。
      IC50和靶点:
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    • Adolf, W., Hecker, E., Balmain, A., et al.“Euphorbiasteroid” (epoxy-lathyrol). A new tricyclic diterpene from Euphorbia lathyris L.Tetrahedron Lett.11(26),2241-2244(1970)

      Park, S.-J., Park, J.H., Han, A., et al.Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells via activation of AMP-activated protein kinaseCell Biochem. Funct.33(4),220-225(2015)

      Guo, F., Li, X., Zhang, C., et al.Roles and mechanisms of Fas/FasL in the apoptosis of HL-60 cells induced by euphorbiasteroidJ. Int. Oncology41(9),679-684(2014)

      Choi, J.S., Kang, N.S., Min, Y.K., et al.Euphorbiasteroid reverses P-glycoprotein-mediated multi-drug resistance in human sarcoma cell line MES-SA/Dx5Phytother. Res.24(7),1042-1046(2010)

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