ALW-II-41-27
Cat. No.：YN440370
CAS No. ：1186206-79-0
规格
价格(RMB)
库存
| 产品名称: | ALW-II-41-27 |
| CAS No.: | 1186206-79-0 |
| Chemical Name: | N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[[[5-(2-thienyl)-3-pyridinyl]carbonyl]amino]-benzamide |
| Synonyms: | Eph receptor tyrosine kinase inhibitor |
| 分子量: | 607.69 |
| 分子式: | C₃₂H₃₂F₃N₅O₂S |
| SMILES: | CC1=C(NC(C2=CC(C3=CC=CS3)=CN=C2)=O)C=C(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ALW-II-41-27是Eph家族酪氨酸激酶抑制剂，抑制Eph2的IC50为11 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Choi, Y., Syeda, F., Walker, J.R., et al.Discovery and structural analysis of Eph receptor tyrosine kinase inhibitorsBioorg. Med. Chem. Lett.19(15),4467-4470(2009)
Terai, H., Tan, L., Beauchamp, E.M., et al.Characterization of DDR2 inhibitors for the treatment of DDR2 mutated nonsmall cell lung cancerACS Chem. Biol.10(12),2687-2696(2015)
Moccia, M., Liu, Q., Guida, T., et al.Identification of novel small molecule inhibitors of oncogenic RET kinasePLoS One10(6),e0128364(2015)
Song, W., Hwang, Y., Youngblood, V.M., et al.Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancersOncogene36(40),5620-5630(2017)
