BI-9564
Cat. No.：YN310008
CAS No. ：1883429-22-8
| 产品名称: | BI-9564 |
| CAS No.: | 1883429-22-8 |
| Chemical Name: | 4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one |
| Synonyms: | BI9564,BI 9564 |
| 分子量: | 353.41 |
| 分子式: | C₂₀H₂₃N₃O₃ |
| SMILES: | CN(C)CC1=CC(OC)=C(C(C2=C3C=NC=C2)=CN(C)C3=O)C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BI-9564 是一种有效的，选择性的且可透过细胞的BRD9/BRD7溴结构域抑制剂，IC50分别为 75 nM 和 3.4μM，Kd为 14 nM 和 239 nM。BI-9564 对 BET 家族的IC50值 > 100 μM。 |
| IC50和靶点: | [{name:"BRD9:75 nM (IC50)"},{name: "BRD9:14 nM (Kd)"},{name: "BRD7:3.4 μM (IC50)"},{name: "BRD7:239 nM (Kd)"}] |
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| Solvent & Solubility: |
Martin, L.J., Koegl, M., Bader, G., et al.Structure-based design of an in vivo active selective BRD9 inhibitorJ. Med. Chem.59(10),4462-4475(2016)
Karim, R.M., and Schönbrunn, E.An advanced tool to interrogate BRD9J. Med. Chem.59(10),4459-4461(2016)
