CPI-637
Cat. No.：YN310012
CAS No. ：1884712-47-3
| 产品名称: | CPI-637 |
| CAS No.: | 1884712-47-3 |
| Chemical Name: | (4R)-1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-2H-1,5-benzodiazepin-2-one |
| Synonyms: | CPI 637 |
| 分子量: | 386.45 |
| 分子式: | C₂₂H₂₂N₆O |
| SMILES: | O=C1NC2=CC=CC(C3=CC4=C(N(C)N=C4C5=CN(C)N=C5)C=C3)=C2N[C@H](C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPI-637 是一种选择性和有效的CBP/EP300溴结构域抑制剂，其对CBP,EP300和BRD4 BD-1的IC50值分别为 0.03 μM，0.051 μM 和 11.0 μM，对CBP的EC50值为 0.3 μM。 |
| IC50和靶点: | [{name:"BRD4 BD1:11 μM (IC50)"}] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Taylor, A.M., Côté, A., Hewitt, M.C., et al.Fragment-based discovery of a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor (CPI-637)ACS Med. Chem. Lett.7(5),531-536(2016)
