666-15
Cat. No.：YN310039
CAS No. ：1433286-70-4
| 产品名称: | 666-15 |
| CAS No.: | 1433286-70-4 |
| Chemical Name: | 3-(3-aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide, monohydrochloride |
| Synonyms: | CREB inhibitor |
| 分子量: | 620.52 |
| 分子式: | C₃₃H₃₁Cl₂N₃O₅ |
| SMILES: | O=C(NC1=CC=C(Cl)C=C1O)C2=CC3=CC=CC=C3C=C2OCCNC(C4=C(OCCCN)C=C(C=CC=C5)C5=C4)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 666-15 是一种有效的选择性CREB抑制剂，IC50为 81 nM。666-15 抑制乳腺癌异种移植模型中的肿瘤生长。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Xie, F., Li, B.X., Kassenbrock, A., et al.Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activityJ. Med. Chem.58(12),5075-5087(2015)
