BMS-986158
Cat. No.：YN310047
| 产品名称: | BMS-986158 |
| CAS No.: | 1800340-40-2 |
| Chemical Name: | 3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-α,α-dimethyl-5-[(S)-phenyl(tetrahydro-2H-pyran-4-yl)methyl]-5H-pyrido[3,2-b]indole-7-methanol |
| Synonyms: | BMS-986158,BMS 986158,BMS986158 |
| 分子量: | 495.62 |
| 分子式: | C₃₀H₃₃N₅O₂ |
| SMILES: | OC(C)(C)C1=CC=C2C(N([C@H](C3=CC=CC=C3)C4CCOCC4)C5=C2N=CC(C6=C(C)N=NN6C)=C5)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-986158 是一种有效的BET抑制剂，在 NCI-H211 小细胞肺癌 (SCLC) 细胞和 MDA-MB231 三阴性乳腺癌 (TNBC) 细胞中，对 BET 的IC50分别为 6.6 和 5nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gavai, A.V., Norris, D., Tortolani, D., et al.Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancerCancer Res.78(13 Supplement),5789-5789(2018)
