KG-501
Cat. No.：YN310061
| 产品名称: | KG-501 |
| CAS No.: | 18228-17-6 |
| Chemical Name: | N-(4-chlorophenyl)-3-(phosphonooxy)-2-naphthalenecarboxamide |
| Synonyms: | Naphthol AS-E phosphate |
| 分子量: | 377.72 |
| 分子式: | C₁₇H₁₃ClNO₅P |
| SMILES: | O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KG-501 是CREB的抑制剂，其 IC50值为 6.89 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Best, J., Amezcua, C.A., Mayr, B., et al.Identification of small-molecule antagonists that inhibit an activator: Coactivator interactionProc. Natl. Acad. Sci. USA101(51),17622-17627(2004)
Uttarkar, S., Dukare, S., Bopp, B., et al.Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300Mol. Cancer Ther.14(6),1276-1285(2015)
Lee, J.W., Park, H.S., Park, S.-A., et al.A novel small-molecule inhibitor targeting CREB-CBP complex possesses anti-cancer effects along with cell cycle regulation, autophagy suppression and endoplasmic reticulum stressPLoS One10(4),e0122628(2015)
