A-485
Cat. No.：YN310083
| 产品名称: | A-485 |
| CAS No.: | 1889279-16-6 |
| Chemical Name: | (1R)-N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide |
| Synonyms: | A485;A 485 |
| 分子量: | 536.48 |
| 分子式: | C₂₅H₂₄F₄N₄O₅ |
| SMILES: | O=C(N1CC(N([C@@H](C)C(F)(F)F)CC2=CC=C(F)C=C2)=O)[C@]3(OC1=O)C4=CC=C(NC(NC)=O)C=C4CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-485 是p300/CBP的强效选择性催化抑制剂，对p300和CBP组蛋白乙酰转移酶(HAT)的IC50值分别为 9.8 nM 和 2.6 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lasko, L.M., Jakob, C.G., Edalgi, R.P., et al.Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumoursNature550(7674),128-132(2017)
