EML 425
Cat. No.：YN310106
CAS No. ：1675821-32-5
| 产品名称: | EML 425 |
| CAS No.: | 1675821-32-5 |
| Chemical Name: | 5-[(4-hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione |
| Synonyms: | |
| 分子量: | 440.49 |
| 分子式: | C₂₇H₂₄N₂O₄ |
| SMILES: | O=C(N(C(N(CC1=CC=CC=C1)C/2=O)=O)CC3=CC=CC=C3)C2=C/C4=C(C=C(O)C=C4C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EML425 是一种有效的选择性 CREB 结合蛋白 (CBP)/p300抑制剂。IC50为 2.9 和 1.1 μM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Milite, C., Feoli, A., Sasaki, K., et al.A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approachJ. Med. Chem.58(6),2779-2798(2015)
Kanada, F., Takamura, Y., Miyake, S., et al.Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataractSci. Rep.9(1),20085(2019)
