CF53
Cat. No.：YN310131
CAS No. ：1808160-52-2
| 产品名称: | CF53 |
| CAS No.: | 1808160-52-2 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 443.50 |
| 分子式: | C₂₄H₂₅N₇O₂ |
| SMILES: | COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(NC5=CC(C6CC6)=NN5C)=NC(C)=N3)C4=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CF53 是一种高效、选择性、可口服的BET抑制剂，对 BRD4 BD1 的Ki值为 <1 nM，Kd值为 2.2 nM，IC50值为 2 nM；CF53 对 BRD2，BRD3，BRD4 和 BRDT BET 蛋白的 BD1 和 BD2 两个结构域都有高亲和性，对其选择性远高于非含溴结构域 BET 蛋白。CF53 在体外和体内都具有显著的抗肿瘤活性。 |
| IC50和靶点: | [{name:"BRD4 (BD1):<1 nM (Ki)"},{name: "BRD4 (BD1):2 nM (IC50)"},{name: "BRD4 (BD1):2.2 nM (Kd)"},{name: "BRD4 (BD2):0.8 nM (Kd)"},{name: "BRD2 (BD2):0.6 nM (Kd)"},{name: "BRD2 (BD1):1.1 nM (Kd)"},{name: "BRD3 (BD2):0.49 nM (Kd)"},{name: "BRD3 (BD1):0.52 nM (Kd)"},{name: "BRDT (BD2):1 nM (Kd)"},{name: "BRDT (BD1):2 nM (Kd)"},{name: "CECR2:570 nM (Kd)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
