MS402
Cat. No.：YN310147
CAS No. ：1672684-68-2
| 产品名称: | MS402 |
| CAS No.: | 1672684-68-2 |
| Chemical Name: | |
| Synonyms: | MS402;MS 402 |
| 分子量: | 370.83 |
| 分子式: | C₂₀H₁₉ClN₂O₃ |
| SMILES: | O=C(NC1=CC=C(OC)C=C1)C2=CC=C(NC3=C(C)C(CC3)=O)C(Cl)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MS402 是一种BD1选择性的BET BrD抑制剂，对BRD4(BD1)，BRD4(BD2)，BRD3(BD1)，BRD3(BD2)，BRD2(BD1)和BRD2(BD2)的Ki分别为 77 nM，718 nM，110 nM，200 nM，83 nM 和 240 nM。MS402 阻断 Th17 细胞分化并改善小鼠结肠炎。 |
| IC50和靶点: | [{name:"BRD4-BD1:77 nM (Ki)"},{name: "BRD2-BD1:83 nM (Ki)"},{name: "BRD3-BD1:110 nM (Ki)"},{name: "BRD3-BD2:200 nM (Ki)"},{name: "BRD2-BD2:240 nM (Ki)"},{name: "BRD4-BD2:718 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
