PFI-3
Cat. No.：YN310172
| 产品名称: | PFI-3 |
| CAS No.: | 1819363-80-8 |
| Chemical Name: | (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-propen-1-one |
| Synonyms: | PFI 3 |
| 分子量: | 321.37 |
| 分子式: | C₁₉H₁₉N₃O₂ |
| SMILES: | OC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PFI-3是高效，选择性，可渗透细胞的SMARCA2/4溴结构域抑制剂，Kd值为89 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ring, H.Z., Vameghi-Meyers, V., Wang, W., et al.Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genomeGenomics51(1),140-143(1998)
Vidler, L.R., Brown, N., Knapp, S., et al.Druggability analysis and structural classification of bromodomain acetyl-lysine binding sitesJ. Med. Chem.55(17),7346-7359(2012)
Park, J.I., Venteicher, A.S., Hong, J.Y., et al.Telomerase modulates Wnt signalling by association with target gene chromatinNature460(7251),66-72(2009)
