A-366
Cat. No.：YN310180
| 产品名称: | A-366 |
| CAS No.: | 1527503-11-2 |
| Chemical Name: | 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3'-[3H]indol]-2'-amine |
| Synonyms: | A 366,A366 |
| 分子量: | 329.44 |
| 分子式: | C₁₉H₂₇N₃O₂ |
| SMILES: | COC1=CC2=C(N=C(N)C23CCC3)C=C1OCCCN4CCCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-366 是一种高效、高选择性的肽竞争性组蛋白甲基转移酶G9a抑制剂，对 G9a 和 GLP 的IC50分别为 3.3 和 38 nM。A-366 比其他 21 种甲基转移酶具有 1000 倍以上的选择性。A-366 是一种有效的Spindlin1-H3K4me3相互作用的抑制剂 (IC50=182.6 nM)。A-366 对人 H3R (Ki=17 nM) 表现出很高的亲和力，并且在组胺能和多巴胺能受体家族的亚群间表现出亚型选择性。 |
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Sweis, R.F., Pliushchev, M., Brown, P.J., et al.Discovery and development of potent and selective inhibitors of histone methyltransferase G9aACS Med. Chem. Lett.5(2),205-209(2014)
Wagner, T., Greschik, H., Burgahn, T., et al.Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platformNucleic Acids Res.,(2016)
