(R)-(-)-JQ1 Enantiomer
Cat. No.：YN310206
CAS No. ：1268524-71-5
| 产品名称: | (R)-(-)-JQ1 Enantiomer |
| CAS No.: | 1268524-71-5 |
| Chemical Name: | (6R) 4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 1,1-dimethylethyl ester |
| Synonyms: | (R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯 |
| 分子量: | 456.99 |
| 分子式: | C₂₃H₂₅ClN₄O₂S |
| SMILES: | O=C(C[C@H]1N=C(C2=C(N3C1=NN=C3C)SC(C)=C2C)C4=CC=C(C=C4)Cl)OC(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (R)-(-)-JQ1 Enantiomer 是 (+)-JQ1的异构体。(+)-JQ1可降低 BRD4 基因表达，而(R)-(-)-JQ1 Enantiomer 没有此作用效果。 |
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Filippakopoulos, P., Qi, J., Picaud, S., et al.Selective inhibition of BET bromodomainsNature468(7327),1067-1073(2010)
Dawson, M.A., Kouzarides, T., and Huntly, B.J.Targeting epigenetic readers in cancerN. Engl. J. Med.367(7),647-657(2012)
