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Molibresib

Cat. No.:YN310207

  • CAS No. :1260907-17-2

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    • 生物活性
    • 参考文献
    • 产品名称: Molibresib
      CAS No.: 1260907-17-2
      Chemical Name: (S)-2-(6-(4-chlorophenyl)-8-methoxy-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
      Synonyms:I-BET762; GSK525762; GSK525762A
      分子量:423.90
      分子式:C₂₂H₂₂ClN₅O₂
      SMILES:ClC1=CC=C(C2=N[C@@H](CC(NCC)=O)C3=NN=C(C)N3C4=CC=C(OC)C=C24)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Molibresib (I-BET762; GSK525762) 是BET 溴结构域抑制剂,IC50为32.5-42.5 nM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • LeRoy, G., Rickards, B., and Flint, S.J.The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcriptionMol. Cell30(1),51-60(2008)

      Hargreaves, D.C., Horng, T., and Medzhitov, R.Control of inducible gene expression by signal-dependent transcriptional elongationCell138(1),129-145(2009)

      Nicodeme, E., Jeffrey, K.L., Schaefer, U., et al.Suppression of inflammation by a synthetic histone mimicNature468(7327),1119-1123(2010)

      Dawson, M.A., Kouzarides, T., and Huntly, B.J.Targeting epigenetic readers in cancerN. Engl. J. Med.367(7),647-657(2012)

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    摩尔浓度计算器方程 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    稀释计算器 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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