MI-3454
Cat. No.：YN310232
| 产品名称: | MI-3454 |
| CAS No.: | 2134169-43-8 |
| Chemical Name: | |
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| 分子量: | 636.73 |
| 分子式: | C₃₂H₃₅F₃N₈OS |
| SMILES: | O=CNC1(C2)CC2(CN3C(C#N)=CC4=C3C=CC(CN5CCC(NC6=C(C=C(CC(F)(F)F)S7)C7=NC(NC)=N6)CC5)=C4C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MI-3454 是一种具有口服活性，高效和选择性的Menin-MLL1相互作用抑制剂，IC50为 0.51 nM。MI-3454 通过下调涉及白血病发生的关键基因，在MLL1重排或NPM1突变的白血病小鼠模型中抑制细胞增殖，诱导分化并完全缓解或消退白血病。 |
| IC50和靶点: | |
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