GSK046
Cat. No.：YN310235
CAS No. ：2474876-09-8
| 产品名称: | GSK046 |
| CAS No.: | 2474876-09-8 |
| Chemical Name: | 4-(acetylamino)-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]-benzamide |
| Synonyms: | iBET-BD2 |
| 分子量: | 414.47 |
| 分子式: | C₂₃H₂₇FN₂O₄ |
| SMILES: | O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK046 (iBET-BD2) 是一种有效，选择性和具有口服活性的BET蛋白BD2溴结构域的抑制剂，IC50值为 264 nM (BRD2 BD2)，98 nM (BRD3 BD2)，49 nM (BRD4 BD2) 和 214 nM (BRDT BD2)。GSK046 具有免疫调节活性。 |
| IC50和靶点: | [{name:"BRD2 BD2:264 nM (IC50)"},{name: "BRD3 BD2:98 nM (IC50)"},{name: "BRD4 BD2:49 nM (IC50)"},{name: "BRDT BD2:214 nM (IC50)"}] |
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| Solvent & Solubility: |
Gilan, O., Rioja, I., Knezevic, K., et al.Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammationScience368(6489),387-394(2020)
