GSK2801
Cat. No.：YN310278
| 产品名称: | GSK2801 |
| CAS No.: | 1619994-68-1 |
| Chemical Name: | 1-[1-[2-(methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]-ethanone |
| Synonyms: | GSK2801,GSK-2801,GSK 2801 |
| 分子量: | 371.45 |
| 分子式: | C₂₀H₂₁NO₄S |
| SMILES: | O=C(C)C1=CC(C2=C(S(=O)(C)=O)C=CC=C2)=C3N1C=CC(OCCC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK2801 是一种有效的，选择性的，口服活性的和细胞活性的乙酰赖氨酸竞争性BAZ2A和BAZ2B溴结构域抑制剂，Kd值分别为 136 nM 和 257 nM。GSK2801 对BAZ2A/B的选择性是 BRD4 的 50 倍以上。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Clapier, C.R., and Cairns, B.R.The biology of chromatin remodeling complexesAnnu. Rev. Biochem.78,273-304(2009)
He, X., Fan, H.Y., Garlick, J.D., et al.Diverse regulation of SNF2h chromatin remodeling by noncatalytic subunitsBiochemistry47,7025-7033(2008)
Chen, P., Chaikuad, A., Bamborough, P., et al.Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2BJ. Med. Chem.,(2015)
Gallenkamp, D., Gelato, K.A., Haendler, B., et al.Bromodomains and their pharmacological inhibitorsChem. Med. Chem.9(3),438-464(2014)
