Birabresib
Cat. No.：YN310281
CAS No. ：202590-98-5
| 产品名称: | Birabresib |
| CAS No.: | 202590-98-5 |
| Chemical Name: | (6S)-4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Synonyms: | OTX-015; MK-8628 |
| 分子量: | 491.99 |
| 分子式: | C₂₅H₂₂ClN₅O₂S |
| SMILES: | O=C(NC1=CC=C(O)C=C1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Birabresib (OTX-015) 是一种有效的BRD2/3/4抑制剂，IC50值为 92-112 nM。 |
| IC50和靶点: | |
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Noel, J.K., Iwata, K., Ooike, S., et al.Development of the BET bromodomain inhibitor OTX015Mol. Cancer Ther.12,C244(2013)
Braun, T., Coude, M.M., Berrou, J., et al.Preclinical study of the bromodomain inhibitor OTX015 in acute myeloid (AML) and lymphoid (ALL) leukemiasBlood122,4218(2014)
Boi, M., Todaro, M., Vurchio, V., et al.OTX015, a bromodomain and extraterminal inhibitor, represents a novel agent for ALK positive anaplastic large cell lymphomaMol. Cancer Ther.12,A219(2013)
