SGC-CBP30
Cat. No.：YN310283
CAS No. ：1613695-14-9
| 产品名称: | SGC-CBP30 |
| CAS No.: | 1613695-14-9 |
| Chemical Name: | 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole |
| Synonyms: | SGCBP30,SGCCBP 30 |
| 分子量: | 509.04 |
| 分子式: | C₂₈H₃₃ClN₄O₃ |
| SMILES: | C[C@H](N1CCOCC1)CN2C(CCC3=CC=C(OC)C(Cl)=C3)=NC4=CC(C5=C(C)ON=C5C)=CC=C42 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SGC-CBP30 是一种有效且高度选择性的CBP/p300溴结构域抑制剂 (对CBP和p300的Kd值分别为 21 nM 和 32 nM)，其选择性是BRD4 [BRD4(1)]的 40 倍。SGC-CBP30 强烈减少 Th17 细胞中 IL-17A 的分泌，并具有抗炎作用。 |
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| Solvent & Solubility: |
Gallenkamp, D., Gelato, K.A., Haendler, B., et al.Bromodomains and their pharmacological inhibitorsChem. Med. Chem.9(3),438-464(2014)
