PFI-4
Cat. No.：YN310306
CAS No. ：900305-37-5
| 产品名称: | PFI-4 |
| CAS No.: | 900305-37-5 |
| Chemical Name: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
| Synonyms: | PFI4 |
| 分子量: | 380.44 |
| 分子式: | C₂₁H₂₄N₄O₃ |
| SMILES: | O=C(NC1=C(N2CCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PFI-4是一种有效的, 渗透细胞的选择性BRPF1 Bromodoman抑制剂, IC50为 80 nM, 作用于BRPF1比作用于其他Bromodoman (包括BRPF2/3和BRD4) 选择性强100多倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ullah, M., Pelletier, N., Xiao, L., et al.Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexesMol. Cell Biol.28(22),6828-6843(2008)
Klein, B.J., Lalonde, M.E., Côté, J., et al.Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexesEpigenetics9(2),186-193(2014)
Demont, E.H., Bamborough, P., Chung, C.W., et al.1,3-Dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomainACS Med. Chem. Lett.5,1190-1195(2014)
