GSK-5959
Cat. No.：YN310307
| 产品名称: | GSK-5959 |
| CAS No.: | 901245-65-6 |
| Chemical Name: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide |
| Synonyms: | GSK-5959,GSK5959 |
| 分子量: | 394.47 |
| 分子式: | C₂₂H₂₆N₄O₃ |
| SMILES: | O=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK-5959 是有效的、选择性的、细胞渗透性的BRPF1溴端结构域的抑制剂，其IC50值为 80 nM。 |
| IC50和靶点: | |
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Ullah, M., Pelletier, N., Xiao, L., et al.Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexesMol. Cell Biol.28(22),6828-6843(2008)
Klein, B.J., Lalonde, M.E., Côté, J., et al.Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexesEpigenetics9(2),186-193(2014)
Demont, E.H., Bamborough, P., Chung, C.W., et al.1,3-Dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomainACS Med. Chem. Lett.5,1190-1195(2014)
