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JQ-1 (carboxylic acid)

Cat. No.:YN310335

  • CAS No. :202592-23-2

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: JQ-1 (carboxylic acid)
      CAS No.: 202592-23-2
      Chemical Name: (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid
      Synonyms:JQ-1 carboxylic acid
      分子量:400.88
      分子式:C₁₉H₁₇ClN₄O₂S
      SMILES:ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@H]4CC(O)=O)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: JQ-1 carboxylic acid 是一种 (+)-JQ1 衍生物 (一种BET溴结构域抑制剂)。JQ-1 carboxylic acid 可作为合成 PROTACs 的前体,靶向BET-溴结构域。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Filippakopoulos, P., Qi, J., Picaud, S., et al.Selective inhibition of BET bromodomainsNature468(7327),1067-1073(2010)

      Dawson, M.A., Kouzarides, T., and Huntly, B.J.Targeting epigenetic readers in cancerN. Engl. J. Med.367(7),647-657(2012)

      Delmore, J.E., Issa, G.C., Lemieux, M.E., et al.BET bromodomain inhibition as a therapeutic strategy to target c-MycCell146(6),904-917(2011)

      Mertz, J.A., Conery, A.R., Bryant, B.M., et al.Targeting MYC dependence in cancer by inhibiting BET bromodomainsProc. Natl. Acad. Sci. USA108(40),16669-16674(2011)

      Dawson, M.A., Prinjha, R.K., Dittmann, A., et al.Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaNature478,529-533(2011)

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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