TPPU
Cat. No.：YN370142
CAS No. ：1222780-33-7
| 产品名称: | TPPU |
| CAS No.: | 1222780-33-7 |
| Chemical Name: | N-[1-(1-oxopropyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy)phenyl)-urea |
| Synonyms: | |
| 分子量: | 359.34 |
| 分子式: | C₁₆H₂₀F₃N₃O₃ |
| SMILES: | O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CC)=O)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TTPU是可溶性环氧化物水解酶(sEH)抑制剂，对猴子和人类的IC50值分别为37和3.7 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Schmelzer, K.R., Kubala, L., Newman, J.W., et al.Soluble epoxide hydrolase is a therapeutic target for acute inflammationProc. Natl. Acad. Sci. USA102(28),9772-9777(2005)
Yu, Z., Xu, F., Huse, L.M., et al.Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acidsCirc. Res.87(11),992-998(2000)
Rose, T.E., Morisseau, C., Liu, J.Y., et al.1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: Structure-activity relationships, pharmacokinetics, and reduction of inflammatory painJ. Med. Chem.53(19),7067-7075(2010)
Tsai, H.J., Hwang, S.H., Morisseau, C., et al.Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogsEur. J. Pharm. Sci.40(3),222-238(2010)
