AUDA
Cat. No.：YN370422
CAS No. ：479413-70-2
| 产品名称: | AUDA |
| CAS No.: | 479413-70-2 |
| Chemical Name: | 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid |
| Synonyms: | |
| 分子量: | 392.58 |
| 分子式: | C₂₃H₄₀N₂O₃ |
| SMILES: | O=C(O)CCCCCCCCCCCNC(NC1(C2)CC3CC2CC(C3)C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AUDA (化合物 43) 是一种有效的可溶性环氧化物水解酶 (sEH) 抑制剂，在小鼠和人 sEH 的IC50分别为 18 和 69 nM。AUDA 具有抗炎活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Morisseau, C., Goodrow, M.H., Newman, J.W., et al.Structural refinement of inhibitors of urea-based soluble epoxide hydrolasesBiochem. Pharmacol.63(9),1599-1608(2002)
Imig, J.D., Zhao, X., Zaharis, C.Z., et al.An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertensionHypertension46(2),975-981(2005)
Fang, X., Hu, S., Watanabe, T., et al.Activation of peroxisome proliferator-activated receptor α by substituted urea-derived soluble epoxide hydrolase inhibitorsJ. Pharmacol. Exp. Ther.314(1),260-270(2005)
