EC5026
Cat. No.：YN371605
CAS No. ：1809885-32-2
| 产品名称: | EC5026 |
| CAS No.: | 1809885-32-2 |
| Chemical Name: | N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N′-[1-[(2S)-2-methyl-1-oxobutyl]-4-piperidinyl]-urea |
| Synonyms: | BPN-19186 |
| 分子量: | 405.39 |
| 分子式: | C₁₈H₂₃F₄N₃O₃ |
| SMILES: | O=C(NC1CCN(C([C@@H](C)CC)=O)CC1)NC2=CC=C(OC(F)(F)F)C(F)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EC5026 (BPN-19186) 是一种首创的，非阿片类的，可溶性环氧水解酶 (sEH) 抑制剂。EC5026 对发炎性和神经性疼痛的有效。 |
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Lee, K.S.S., Ng, J.C., Yang, J., et al.Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic painBioorg. Med. Chem.28(22),115735(2020)
Hammock, B.D., McReynolds, C.B., Wagner, K., et al.Movement to the clinic of soluble epoxide hydrolase inhibitor EC5026 as an analgesic for neuropathic pain and for use as a nonaddictive opioid alternativeJ. Med. Chem.64(4),1856-1872(2021)
