GCN2-IN-1
Cat. No.：YN290019
CAS No. ：1448693-69-3
| 产品名称: | GCN2-IN-1 |
| CAS No.: | 1448693-69-3 |
| Chemical Name: | 3-(1H-indazol-6-yl)-N-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine |
| Synonyms: | A-92 |
| 分子量: | 402.41 |
| 分子式: | C₁₉H₁₈N₁₀O |
| SMILES: | C1(NC2=CN(C3CCOCC3)N=C2)=NC=C(N=NN4C5=CC6=C(C=C5)C=NN6)C4=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GCN2-IN-1 (A-92) 是一种有效的一般性调控阻遏蛋白激酶 2 (GCN2) 抑制剂，在酶实验中，IC50<0.3 μM，细胞实验中IC50为 0.3-3 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Torres, C., Garling, A., Taouji, S., et al.Targeting the integrated stress response kinase GCN2 to modulate retroviral integrationMolecules26(17),5423(2021)
Filippova, N., Yang, X., Ananthan, S., et al.Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitorsCancer Res.81(8),2220-2233(2021)
