SA57
Cat. No.：YN370275
| 产品名称: | SA57 |
| CAS No.: | 1346169-63-8 |
| Chemical Name: | 4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylic acid-2-(methylamino), 2-oxoethyl ester |
| Synonyms: | SA57;SA 57 |
| 分子量: | 338.83 |
| 分子式: | C₁₇H₂₃ClN₂O₃ |
| SMILES: | O=C(N1CCC(CCC2=CC=C(Cl)C=C2)CC1)OCC(NC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SA57 是一种有效的选择性FAAH抑制剂，对小鼠和人类FAAH的IC50分别为 3.2 nM 和 1.9 nM。SA57 还抑制 2-花生四烯酸甘油水解酶MAGL(对小鼠和人类MAGL的IC50分别为 410 nM 和 1.4 μM）和小鼠 α/β-水解酶结构域蛋白 6 (mABHD6;IC50为 850 nM)，但不抑制其他脑丝氨酸水解酶。 |
| IC50和靶点: | |
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Niphakis, M.J., Johnson, D.S., Ballard, T.E., et al.O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitorsACS Chem Neurosci.3(5),418-426(2012)
Ramesh, D., Gamage, T.F., Vanuytsel, T., et al.Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent miceNeuropsychopharmacology38(6),1039-1049(2013)
