LY2183240
Cat. No.：YN370429
| 产品名称: | LY2183240 |
| CAS No.: | 874902-19-9 |
| Chemical Name: | 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide |
| Synonyms: | LY-2183240, LY 2183240 |
| 分子量: | 307.35 |
| 分子式: | C₁₇H₁₇N₅O |
| SMILES: | O=C(N(C)C)N1N=NN=C1CC(C=C2)=CC=C2C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY2183240是高活性大麻素吸收阻断剂，IC50为270 pM，还能抑制脂肪酸酰胺水解酶（FAAH），IC50为12.4 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Moore, S.A., Nomikos, G.G., Dickason-Chesterfield, A.K., et al.Identification of a high-affinity binding site involved in the transport of endocannabinoidsProc. Natl. Acad. Sci. USA102(49),17852-17857(2005)
Ortar, G., Cascio, M.G., Moriello, A.S., et al.Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitationEur. J. Med. Chem.43,62-72(2008)
Di Marzo, V.Targeting the endocannabinoid system: To enhance or reduce?Nat. Rev. Drug Discov.7,438-455(2008)
