HTS01037
Cat. No.：YN370170
CAS No. ：682741-29-3
| 产品名称: | HTS01037 |
| CAS No.: | 682741-29-3 |
| Chemical Name: | 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-[2,2'-bithiophene]-5-carboxylic acid, 5-methyl ester |
| Synonyms: | HTS01037;HTS-01037 |
| 分子量: | 337.37 |
| 分子式: | C₁₄H₁₁NO₅S₂ |
| SMILES: | O=C(C1=C(NC(/C=C/C(O)=O)=O)C=C(C2=CC=CS2)S1)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HTS01037是结合脂肪酸的抑制剂。它也是由AFABP / aP2介导的蛋白质-蛋白质相互作用的拮抗剂，Ki值为0.67 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Massolini, G., and Calleri, E.Survey of binding properties of fatty acid-binding proteins chromatographic methodsJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.797(1-2),255-268(2003)
Perrella, M.A., Pellacani, A., Layne, M.D., et al.Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic miceFASEB J.15(10),1774-1776(2001)
Furuhashi, M., Tuncman, G., Görgün, C.Z., et al.Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2Nature447,959-965(2007)
Hertzel, A.V., Hellberg, K., Reynolds, J.M., et al.Identification and characterization of a small molecule inhibitor of fatty acid binding proteinsJ. Med. Chem.52,6024-6031(2009)
