Kukoamine A
Cat. No.：YN251600
| 产品名称: | Kukoamine A |
| CAS No.: | 75288-96-9 |
| Chemical Name: | N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-benzenepropanamide] |
| Synonyms: | 地骨皮甲素 |
| 分子量: | 530.66 |
| 分子式: | C₂₈H₄₂N₄O₆ |
| SMILES: | O=C(NCCCNCCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Kukoamine A 是一种天然的精胺衍生物，为有效的锥虫硫磷还原酶 (trypanothione reductase) 抑制剂，Ki值为 1.8 μM。具有抗高血压活性。 |
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Funayama, S., Yoshida, K., Konno, C., et al.Structure of kukoamine A, a hypotensive principle of Lycium chinense root barksTetrahedron Lett.21(14),1355-1356(1980)
Wang, Q., Li, H., Sun, Z., et al.Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuationSci. Rep.6,36543(2016)
Hu, X., Song, Q., Li, X., et al.Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancementNeuropharmacology117,352-363(2017)
Zhang, Y., Gao, L., Cheng, Z., et al.Kukoamine A prevents radiation-induced neuroinflammation and preserves hippocampal neurogenesis in rats by inhibiting activation of NF-κB and AP-1Neurotox. Res.31(2),259-268(2017)
Ponasik, J.A., Strickland, C., Faerman, C., et al.Kukoamine A and other hydrophobic acylpolyamines: Potent and selective inhibitors of Crithidia fasciculata trypanothione reductaseBiochem. J.311(Pt 2),371-375(1995)
