PF-562271 besylate
Cat. No.：YN440095
CAS No. ：939791-38-5
规格
价格(RMB)
库存
| 产品名称: | PF-562271 besylate |
| CAS No.: | 939791-38-5 |
| Chemical Name: | N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide, monobenzenesulfonate |
| Synonyms: | PF562271 besylate; PF 562271 besylate |
| 分子量: | 665.66 |
| 分子式: | C₂₇H₂₆F₃N₇O₆S₂ |
| SMILES: | CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O.O=S(C5=CC=CC=C5)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-562271 besylate 是有效，可逆，ATP竞争性的FAK和Pyk2激酶抑制剂，IC50分别为 1.5 和 13 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Parsons, J.T., Slack-Davis, J., Tilghman, R., et al.Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic interventionClin. Cancer Res.14(3),627-632(2008)
Roberts, W.G., Ung, E., Whalen, P., et al.Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271Cancer Res.68(6),1935-1944(2008)
Stokes, J.B., Adair, S.J., Slack-Davis, J.K., et al.Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironmentMol. Cancer Ther.10(11),2135-2145(2011)
