PF-573228
Cat. No.：YN440098
CAS No. ：869288-64-2
规格
价格(RMB)
库存
| 产品名称: | PF-573228 |
| CAS No.: | 869288-64-2 |
| Chemical Name: | 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone |
| Synonyms: | PF 573228 |
| 分子量: | 491.49 |
| 分子式: | C₂₂H₂₀F₃N₅O₃S |
| SMILES: | O=C1NC2=C(C=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC(S(=O)(C)=O)=C4)=N3)C=C2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-573228是有效的和选择性的FAK抑制剂，对FAK纯化重组催化片段的IC50值为4 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Parsons, J.T., Slack-Davis, J., Tilghman, R., et al.Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic interventionClin. Cancer Res.14(3),627-632(2008)
Medina, J.F., Haeggström, J., Kumlin, M., et al.Leukotriene A4: Metabolism in different rat tissuesBiochim. Biophys. Acta961,203-212(1988)
Slack-Davis, J.K., Martin, K.H., Tilghman, R.W., et al.Cellular characterization of a novel focal adhesion kinase inhibitorJ. Biol. Chem.282(20),14845-14852(2007)
