Y15
Cat. No.：YN440213
CAS No. ：4506-66-5
规格
价格(RMB)
库存
| 产品名称: | Y15 |
| CAS No.: | 4506-66-5 |
| Chemical Name: | 1,2,4,5-benzenetetramine, tetrahydrochloride |
| Synonyms: | FAK Inhibitor 14 |
| 分子量: | 284.01 |
| 分子式: | C₆H₁₄Cl₄N₄ |
| SMILES: | [H]Cl.[H]Cl.[H]Cl.[H]Cl.NC1=CC(N)=C(N)C=C1N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Y15是一种有效，特异性的粘着斑激酶抑制剂 (FAK)，可抑制其自身磷酸化活性，降低癌细胞的活力，阻断肿瘤生长。 |
| IC50和靶点: | |
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Parsons, J.T., Slack-Davis, J., Tilghman, R., et al.Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic interventionClin. Cancer Res.14(3),627-632(2008)
Golubovskaya, V.M., Nyberg, C., Zheng, M., et al.A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growthJ. Med. Chem.51(23),7405-7416(2008)
Hochwald, S.N., Nyberg, C., Zheng, M., et al.A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancerCell Cycle8(15),2435-2443(2009)
Beierle, E.A., Ma, X., Stewart, J., et al.Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastomaCell Cycle9(5),1005-1015(2010)
Saphirstein, R.J., Gao, Y.Z., Jensen, M.H., et al.The focal adhesion: A regulated component of aortic stiffnessPLoS One8(4),(2013)
