NVP-TAE 226
Cat. No.：YN440253
CAS No. ：761437-28-9
规格
价格(RMB)
库存
| 产品名称: | NVP-TAE 226 |
| CAS No.: | 761437-28-9 |
| Chemical Name: | 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-benzamide |
| Synonyms: | TAE226 |
| 分子量: | 468.94 |
| 分子式: | C₂₃H₂₅ClN₆O₃ |
| SMILES: | O=C(C1=C(C=CC=C1)NC2=NC(NC3=C(C=C(C=C3)N4CCOCC4)OC)=NC=C2Cl)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-TAE 226 (TAE226) 是一种有效且具有 ATP 竞争性的双重FAK和IGF-1R抑制剂，IC50分别为 5.5 nM、140 nM。NVP-TAE 226 (TAE226) 还有效抑制Pyk2，胰岛素受体(InsR)，IC50分为 3.5 nM、40 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Liu, T.-J., LaFortune, T., Honda, T., et al.Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivoMol. Cancer Ther.6(4),1357-1367(2007)
Halder, J., Lin, Y.G., Merritt, W.M., et al.Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinomaCancer Res.67(22),10976-10983(2007)
