Fangchinoline
Cat. No.：YN440427
CAS No. ：436-77-1
规格
价格(RMB)
库存
| 产品名称: | Fangchinoline |
| CAS No.: | 436-77-1 |
| Chemical Name: | (4aS,16aS)-3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol |
| Synonyms: | 防己诺林碱 |
| 分子量: | 608.72 |
| 分子式: | C₃₇H₄₀N₂O₆ |
| SMILES: | OC1=C(OC2=CC([C@]3([H])CC(C=C4)=CC=C4O5)=C(CCN3C)C=C2OC)C([C@](N6C)([H])CC7=CC=C(OC)C5=C7)=C(CC6)C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fangchinoline 从Stephaniatetrandra中分离出来的，具有广泛的生物学活性，例如增强免疫力，消炎杀菌和抗动脉粥样硬化。Fangchinoline 是新型HIV-1抑制剂，通过损害 gp160 蛋白水解过程来抑制 HIV-1 复制。Fangchinoline 靶向Focal adhesion kinase (FAK)并抑制肿瘤细胞中 FAK 介导的的信号传导途径。Fangchinoline 诱导膀胱癌的凋亡 (apoptosis) 和适应性自噬 (autophagy)。 |
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Choi, H.S., Kim, H.S., Min, K.R., et al.Anti-inflammatory effects of fangchinoline and tetrandrineJ. Ethnopharmacol.69(2),173-179(2000)
Cho, S.O., and Seong, Y.H.Protective effect of fangchinoline on cyanide-induced neurotoxicity in cultured rat cerebellar granule cellsArch. Pharm. Res.25(3),349-356(2002)
Wang, C.D., Huang, J.G., Gao, X., et al.Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograftBiosci. Biotechnol. Biochem.74(3),488-493(2010)
